Generic Zetia Online Reviews

Generic Zetia Online Reviews

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The effects of ezetimibe generic Zetia Online Reviews generic Zetia alone or in addition to a statin or fenofibrate on cardiovascular morbidity and mortality have not been established. There was no generic Zetia Online Reviews deviation from dose proportionality between 5 and 20 mg. Metabolism And Excretion Ezetimibe is primarily metabolized in the small intestine and liver via glucuronide conjugation a phase II reaction with subsequent biliary and renal excretion.

Minimal oxidative metabolism a phase I reaction has been observed in all species evaluated. In humans, ezetimibe is rapidly metabolized to ezetimibe-glucuronide.

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Both ezetimibe and ezetimibe-glucuronide are eliminated from plasma with a half-life of approximately 22 hours for both ezetimibe and ezetimibeglucuronide. Plasma concentration-time profiles exhibit multiple peaks, suggesting enterohepatic recycling. After 48 hours, there were no detectable levels of radioactivity in the plasma.